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. KOSTROVA, G. STRUCHKO, L. MERKULOVA, M. MIKHAYLOVA, E. MOSKVICHEV MORPHOFUNCTIONAL CHANGES IN THE THYMUS AGAINST THE DEVELOPMENT OF PRECANCEROUS DISEASES OF THE COLON Key words: carcinogenesis, thymic involution, mast cells, dendritic cells.
It is established that with the appearance in the large intestine in experimental animals precan-cerous changes develops accidental involution of the thymus1 and 2 phase. This is expressed deformation of the lobules, the fatty degeneration of the thymus, the imbalance of biogenic amines levels, the reducing of the cortex and medulla size in the background of a parallel decrease in weight of the thymus, and also increase of the number of mast and dendritic cells.
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17. Crivellato E., Nico ., Ribatti D. Mast cell contribution to tumor angiogenesis: a clinical aa-proach // Eur. Cytokine Netw. 2009. Vol. 20(4). P. 197-206.
18. Accidental involution of thymus / D. Lyden, R. Hattor, S. Dias et al. // Nature med. 2001. Vol. 7, 11.
19. Dabbs D.J. Diagnostics immunohistochemistry. Edinburg: Churchill Livingston, 2002. 637 .
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KOSTROVA OLGA - oandidate of medical sciences, assistant of Functional and Laboratory Diagnostic Chair, Chuvash State University, Russia, Cheboksary.
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STRUCHKO GLEB - doctor of medical sciences, professor, head of Functional and Laboratory Diagnostic Chair, Chuvash State University, Russia, Cheboksary.
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MERKULOVA LARISA - doctor of medical sciences, professor, head of Normal and Topographic Anatomy Chair, Chuvash State University, Russia, Cheboksary.
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MIKHAYLOVA MARINA - oandidate of medical sciences, ssociate rofessor of Normal and Topographic Anatomy Chair, Chuvash State University, Russia, Cheboksary.
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MOSKVICHEV EVGENII - aandidate of medical sciences, ssociate rofessor of Normal and Topographic Anatomy Chair, Chuvash State University, Russia, Cheboksary.