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616-022.854.2-06-07-036-037
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SE "Dnipropetrovsk medical academy Ministry of Health of Ukraine"
Department of family medicine
Dzerzhinsky Str., 9, Dnipropetrovsk, 49044, Ukraine
e-mail: evgeniya_s.v.88@mail.ru
: , IgE, , Key words: pollinosis, IgE, defect of phagocytosis, pollen bronchial asthma
. , . .., .. 59 , - 39 20 18 68 . . : , . , . . , , (IgE) - , IgE . IgE . , IgE, , . , . , IgE, , 1, . , , - , . , , , .
Abstract. Methods of early revealing, prognosis of further course and complications of pollinosis. Chukhrienko N.D., Grabovskaya Ye.G. Under our observation there were 59 patients with pollinosis - 39 females and 20 males at the age from 18 to 68 years. All patients were in the phase of disease exacerbation. General clinical symptoms were: rhinitis, conjunctivitis and bronchial spasm. The results showed that first clinical manifestations appear in persons of young age. Half of the patients had aggravated allergologic anamnesis. Taking into account that pollinosis is a typical representative of diseases having mechanism of immunoglobulin E (IgE)-dependent allergic reactions of the first type, the authors have studied in detail level of IgE and its link with other factors. Practically in all patients with pollinosis level of total IgE exceeded the norm. As a result of studies performed, it was established that high IgE level, presence of phagocytosis defect and prolong duration of illness are the criteria which affect disease progress, aggravation of patients state, less efficacy of treatment. Due to the fact that development of bronchial obstruction and transformation of pollinosis into bronchial asthma is the most topical issue nowadays, the authors studied its link with other factors and findings. It was established that risk of pollinosis transformation into pollen bronchial asthma increases in the presence of high level of total IgE, aggravation of allergologic anamnesis, decrease offorced expiration volume (FEV), significant duration of disease course. In the course of investigation it was revealed that the highest efficacy of treatment is noted in patients receiving allergen-specific therapy; this confirms data of world scientific literature. The best treatment results are observed in pollinosis patients, with aggravated family history not in parents but in grandparents.
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(33,9%) 18 68 , (M±m) - 38,3±1,4 . ( ) 1 32 11,9±1,0 .
[5].
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: 0 - ; 1 - ; 2 - ; 3 - ; 4 - ( .. ).
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(n=30; 50,8%), () (n=24; 40,7%). ,
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(r = -0,26) - 35,6 ± 1,7 41,1 ± 2,2 ( < 0,05).
, , IgE- , IgE . (n=53; 89,8%) IgE (<100 /),
(Me±m) - 312,3 ± 26,7 /, (25%-75%) - 155,2 - 1051,0 /.
, IgE (. 1):
- (r = -0,46),
, - . (Me±m) - 3,70 ± 0,11 . 2,80-4,60 . 7 (11,9%) . , --, , , IgE. , , , , - ;
- ( = 0,35);
- (r = 0,27);
- (r = -0,26).
. 1. - IgE: r - , * - < 0,05; ** - < 0,01
, IgE .
, . ( - , , ,
) 40 (67,8%) . (40,2 ± 2,1 ), (34,5 ± 3,0 ; > 0,10); (40,0% 21,1% ; > 0,10) (25,0% 10,5%; > 0,10).
(. 2) , :
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- IgE (r = 0,35). , IgE - 2,4 ( < 0,01) -(413,5 ± 33,3) / (169,1 ± 40,8) / (. 1);
- 1 (r = -0,26), 10% -
78,8 ± 2,6% 87,6 ± 2,9% ( < 0,05);
- (r = -0,37). , ( 2,0 ± 0,1 %), 90% , , ;
- (r = 0,36). , 90% , 60% ( < 0,05);
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- (r = 0,27), .
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, 1 - (M±m (Me)) - 4,12 ± 0,05 . (4,0) , ї.
1
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(n=40) (n=19)
IgE , / Me±m 413,5 ± 33,3 169,1 ± 40,8 0,008*
(25%-75%) (231,9 - 1180) (113,6 - 285,5)
, % Me±m 2,0 ± 0,09 4,0 ± 0,20 0,025*
(25%-75%) (1,0 - 4,0) (2,0 - 6,0)
, % M±m 78,8 ± 2,6 87,6 ± 2,9 0,026
(25%-75%) (65,5 - 90,5) (77,0 - 97,0)
, M±m 13,2 ± 1,1 9,2 ± 1,7 0,050
(25%-75%) (5,5 - 20,0) (2,0 - 12,0)
. * - -, - .
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, - () - . , , 90% -
. - , . (. 3).
. 3. - - : r - , * - < 0,05; ** - < 0,01, *** - < 0,001.
, :
- , (r = 0,35), (r = 0,26), (, ) (r = 0,27); (r = 0,26).
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1. .. -- / .. , .. // . - 2003. - 4. - . 14-17.
2. .. / .. . - ., 2006. - 482 .
3. .. / .. , .. // . -2002. - 3. - . 20-25.
4. / .. , .. , .. [ .] // Consilium medicum. -2001. - . - . 33-44.
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5. . ( ) / . , ., . . - ., 2000. - 734 .
6. 02.04.2002.: 127/18. - ., 2002.
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STATISTICA / . . . - .: , 2002. - 312 .
9. . . - / .. , . . . - : , 2002. - 266 .
10. Allergen immunoltherapy: Therapeutic vaccines for allergic diseases. A WHO position paper // Int. J. Im-munorehabil. - 2000. - Vol. 2, N 3. - C. 52-57.
11. Allergic rhinitis and its impact on asthma (ARIA) / J. Bousquet, P. Van Cauwenberge, N. Khaltaev and Workshop Expert Panel // Allergy. - 2002. - Vol. 57, N 9. - P. 841-855.
REFERENCES
1. Aleshina RM, Leykina VV. Combined alergen-specific immunoterapiya for patients pollinozom and objective tests of its efficiency. Asthma and allergy. 2003;4:14-7.
2. Drannik GN. Clinical immunology and alergo-logiya 2006;482.
3. Zabolotniy DI, Pukhlik BM. Rhinallergosis. Treatment and diagnostics. 2002;3:20-5.
4. Lopatin AS, Gushchin IS, Emel'yanov AV. Clinical recommendations on diagnostics and treatment of rhinallergosis. Consilium medicum. 2001;33-44.
5. Patterson R, Grimer L, Grinberg P. Allergic diseases. Treatment and diagnostics. 2000:734.
6. MOZ UkramiAbout organizational measures on
introduction of modern technologies of diagnostics and treatment of allergic diseases from 02.04.2002y. Nakaz MOZ Ukrai'ni 127/18. 2002.
7. Pukhlik BM. Elementary allergology. 2002;148.
8. Rebrova OYu. Statistical analysis of medical data. Application of application of package STATISTICA. 2002;312.
9. Yunkerov VI, Grigor'ev SG. Matematiko-sta-tistical treatment of these medical researches. 2002;266.
10. Immunorehabil J. Allergen immunoltherapy: Therapeutic vaccines for allergic diseases. 2000;3(2):52-57.
11. Bousquet J, Khaltaev N. Allergic rhinitis and its impact on asthma (ARIA) Allergy. 2002;9(57):841-55.

616.832.94-005.1:616.13-007.64-001.18-08
C. .

. .. . , 14, , 49000, Dnipropetrovs k Regional Hospital Oktyabrska sq., 14, Dnipropetrovsk, 49000, Ukraine e-mail: dudukina@ukr.net
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Key words: subarachnoid hemorrhage, preventive, hypothermia hypocalaemia, cardiological complications
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